The Citizens bounced back from successive league draws to beat Aston Villa by a 4-1 scoreline on Wednesday night, thanks to a Phil Foden hat-trick and an early strike from Rodri.
Pep Guardiola's men remain third in the table and, at the time of writing, are level on points with second-placed Liverpool, while they are only one point behind leaders Arsenal.
Man City do not have a fully fit squad at present, and here, Sports Mole rounds up their latest injury and suspension news ahead of the contest with Oliver Glasner's side.
Kyle Walker
Status: Out
Type of injury: Hamstring
Possible return date: April 9 (vs. Real Madrid)
Kyle Walker is expected to miss Saturday's trip to Selhurst Park and is facing a race against time to be fit for next Tuesday's Champions League clash with Real Madrid, after Guardiola stated earlier this week that the defender's injury is "quite serious".
Nathan Ake
Status: Out
Type of injury: Unspecified
Possible return date: Unknown
Nathan Ake missed City's win over Villa after picking up an unspecified injury in the draw with Arsenal last weekend, and it remains to be seen when the defender will be fit to return to first-team action.
Ederson
Status: Major doubt
Type of injury: Muscle
Possible return date: Unknown
Ederson has been sidelined since being forced off with a muscle injury in City's 1-1 draw with Liverpool on March 10, and it remains to be seen when the goalkeeper will be fit to return to first-team action.
John Stones
Status: Minor doubt
Type of injury: Groin
Possible return date: April 6 (vs. Crystal Palace)
After sustaining a groin injury on international duty with England, John Stones has since watched on as an unused substitute in City's last two games and he is expected to be named in the matchday squad once again on Saturday.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.