The Citizens enter this contest in buoyant mood after beating rivals Manchester United on penalties to win the Community Shield last weekend, following a 1-1 draw in 90 minutes at Wembley Stadium.
Pep Guardiola's side had previously beaten Chelsea by a 4-2 scoreline in their final friendly fixture of their pre-season tour in the United States.
Ahead of Man City's trip to the capital this weekend, Sports Mole rounds up their latest injury and suspension news.
Oscar Bobb
Status: Out
Type of injury: Leg fracture
Possible return date: Unknown
Oscar Bobb, who was a standout performer for Man City in pre-season, reportedly sustained a fracture to a bone in his leg during a non-contact situation in Wednesday's training session and the attacker is facing a lengthy spell on the sidelines.
Jack Grealish
Status: Minor doubt
Type of injury: Knock
Possible return date: August 18 (vs. Chelsea)
Guardiola has admitted that Jack Grealish, who missed the Community Shield, is nursing some 'discomfort' and is a doubt for Saturday after he picked up a knock in training.
MANCHESTER CITY'S SUSPENSION LIST
Manchester City have no suspended players for this match.