Enzo Maresca's side have been in free-scoring form of late, their latest victory being by a 4-2 scoreline versus Brighton & Hove Albion in the Premier League on Saturday.
As a result, the Blues currently sit in fourth position in the standings, but Maresca is expected to select a heavily-rotated side for this contest.
Here, Sports Mole rounds up Chelsea's injury and suspension news ahead of welcoming their Belgian opponents to the capital.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
James has suffered a setback in his recovery from his latest hamstring problem, and Maresca recently admitted that he was unsure when the club captain would be available for selection.
CHELSEA'S SUSPENSION LIST
While Chelsea have no players suspended for this fixture, the likes of Wesley Fofana, Romeo Lavia and Cole Palmer were left out of the squad for this competition as Maresca looks to manage their respective game time.
Monaco 
Stade Brestois 29 
Bordeaux 
Nimes 
Bayern Munich 
FC Augsburg 
Paris Saint Germain 
Toulouse 
CSKA Moscow 
FC Rostov 
Leicester 
Chelsea 
Valencia 
Betis 
Dynamo Kyiv 
Chornomorets Odesa 
Verona 
Inter 
Bayer Leverkusen 
FC Heidenheim 
Borussia Dortmund 
SC Freiburg 
VFL Wolfsburg 
Union Berlin 
Arsenal 
Nottingham Forest 
Everton 
Brentford 
Spartak Moscow 
Lokomotiv Moscow 
Rangers 
Dundee Utd 
Atletico Madrid 
Alaves 
Lens 
Marseille 
Ingulets Petrove 
Shakhtar Donetsk 
AC Milan 
Juventus 
ST Malo 
Manchester City 
Tottenham 
Eintracht Frankfurt 
Werder Bremen 
Girona 
Espanyol 
Feyenoord 
Heerenveen 
ST Etienne 
Montpellier 
Grenoble Foot 38 
Heart Of Midlothian 
Celtic 
Reims 
Lyon 
PSV 
Groningen