The Blues entered the international break in high spirits following back-to-back home wins over Newcastle United and Leicester City, beating the latter 4-2 to progress to the FA Cup semi-finals.
Mauricio Pochettino and co now shift their attention back to the Premier League where they currently sit 11th in the table, five points behind London rivals West Ham United in seventh and eight points adrift of sixth-placed Manchester United, who they face next Thursday.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the contest with Vincent Kompany's side.
Romeo Lavia
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Chelsea have confirmed that Romeo Lavia, who has featured for just 32 minutes in his debut campaign at Stamford Bridge, will miss the rest of the season following a setback in his recovery from a "significant thigh injury".
Christopher Nkunku
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Christopher Nkunku, who has been plagued with injuries throughout this season, is currently nursing a hamstring problem, and while a return to first-team action is thought to be not too far away, Saturday's game will likely come too soon for the attacker.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Wesley Fofana has not made a single appearance for Chelsea this season due to a long-term knee injury and the defender is facing a race against time to return before the end of the campaign.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Reece James underwent hamstring surgery just before Christmas and it remains to be seen whether the Chelsea captain will recover before the end of the season.
Lesley Ugochukwu
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Lesley Ugochukwu picked up a hamstring injury in the loss to Wolverhampton Wanderers on Christmas Eve and there is still no timescale on his potential return.
Malo Gusto
Status: Minot doubt
Type of issue: Illness
Possible return date: March 30 (vs. Burnley)
Malo Gusto was forced to withdraw from the France Under-21s squad last week due to illness. The right-back is set to be assessed ahead of kickoff, but he should be fit to feature on Saturday.
Carney Chukwuemeka
Status: Minor doubt
Type of issue: Fitness
Possible return date: March 30 (vs. Burnley)
Carney Chukwuemeka withdrew from England Under-21 duty last week in order "to work on his fitness at Cobham" and the midfielder is due to be assessed ahead of kickoff.
Levi Colwill
Status: Minor doubt
Type of injury: Toe
Possible return date: March 30 (vs. Burnley)
Colwill has missed the last two games with a toe problem and the defender will need to be assessed before it is determined whether he will be available this weekend.
CHELSEA'S SUSPENSION LIST
Chelsea have no suspended players for this match.