The England international watched from the bench as the Villans shared the spoils with Juventus in the Champions League on Tuesday night, with Diego Carlos partnering Pau Torres at centre-back.
The Brazilian is likely to drop out of the side to make room for Konsa, whilst Matty Cash and Lucas Digne are set to keep their spots at full-back.
Suffering a serious injury in February, Frenchman Boubacar Kamara is preparing to make his first Premier League start of the term after earning substitute appearances versus Liverpool, Bournemouth and Tottenham Hotspur recently.
Despite a dip in form, recent Three Lions debutant Morgan Rogers should keep hold of his spot in the Villans' attack, with Leon Bailey and John McGinn also starting behind the main striker.
After his side drew a uninspiring blank against the Old Lady earlier in the week, Unai Emery might be tempted to throw super-sub Jhon Duran into the XI at the expense of Ollie Watkins, although we feel that the England star will probably retain his berth.
Villa travel to West London without the services of Jacob Ramsey, who has not featured since the beginning of November due to a hamstring injury.
Aston Villa possible starting lineup: Martinez; Cash, Konsa, Torres, Digne; Kamara, Tielemans, Bailey, McGinn, Rogers; Watkins