The Italian will be tempted to stick with the same players in some areas of the pitch in an effort to establish more stability, yet this is the third of six pre-season games and he may prefer to keep players fresh.
Carney Chukwuemeka has played the joint-most minutes of pre-season thus far and could drop down to the substitutes' bench for this contest.
Wesley Fofana may be replaced by Tosin Adarabioyo having come through another 45 minutes on his comeback from a serious injury.
New signing Renato Veiga may be tried in central midfield alongside Lesley Ugochukwu, with Reece James and Romeo Lavia potentially handed a rest.
Malo Gusto could be included at right wing-back, with Tyrique George deployed on the opposite side of the pitch after his brief outing against Celtic.
Christopher Nkunku, like Chukwuemeka, has completed 90 minutes in one of the opening two games, which could result in Armando Broja getting a start on Wednesday after he missed out at the weekend.
Raheem Sterling will likely be handed an opportunity from the opening whistle, as will Angelo who is striving to earn a spot at Chelsea this season.
Chelsea possible starting lineup: Sanchez; Adarabioyo, Badiashile, Colwill; Gusto, Ugochukwu, Veiga, George; Sterling, Angelo; Broja