The Blues are 11th in the Premier League table and need a win to improve upon what could be a dismal campaign.
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Brentford, who are above them in 10th, claimed a 4-1 victory at Stamford Bridge last season.
Interim boss Frank Lampard has named his starting line-up for the west London derby, but many fans have been left unimpressed.
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Raheem Sterling is the only recognised attacker who starts for the Blues, with Conor Gallagher potentially joining him up front.
"Absolutely disgraceful team," said one Chelsea fan before adding: "Nothing to play for. Kepa over Mendy. Ziyech, Pulisic, Auba & Felix all in the squad over Chukwuemeka."
Another said: "That is the worst Chelsea team I've ever seen not even joking."
A third fan is already calling for Mauricio Pochettino's arrival as they said: "Horrendous, Madueke, Mudryk, Badashile should all be playing. Wish the season would end and Poch can be here."
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talkSPORT understands former Tottenham boss Mauricio Pochettino has reached a verbal agreement with Chelsea to become their new manager.
He is set to take charge from next season, with Lampard remaining until the end of the season.
However, the club legend has lost all of the games he has taken charge of since returning at the helm.
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Chelsea know they won't have an easy ride against Brentford, even though the Bees are winless in six games.
You can listen to live commentary of the west London derby on the talkSPORT app.