While the Sardinian side shut out Roma to earn an opening-day draw, the visitors were swept aside by Juventus on their top-flight return.
Match preview
After two competitive matches as Cagliari boss, survival specialist Davide Nicola remains undefeated, as he takes on the task of succeeding folk hero Claudio Ranieri.
Starting with back-to-back home games, the Rossoblu first won their Coppa Italia first-round tie against Carrarese, before hosting Roma on Serie A's opening weekend.
The capital club ultimately left Sardinia with just one point, as Cagliari held out for a 0-0 draw that featured Roberto Piccoli's league debut for his latest loan club.
While Piccoli could not follow up on his brace in the cup, keeping a clean sheet against one of Italy's top sides represents a solid start for Nicola, who will now aim to continue in that vein.
After their first-day draw, Cagliari can remain unbeaten in both of their first two Serie A fixtures for the first time since 2011, and they will have home advantage once again.
It has been some 42 years since Como last met Cagliari in the top flight, having mostly lingered in the lower leagues during that time, and the Lariani's main quest this year is to retain their Serie A status.
After two decades away, the Lombardy club are making their comeback under head coach Cesc Fabregas, who has been backed by the richest owners in Italian football.
Collectively, they have ambitions of making a major impact in the seasons ahead, and high-profile signings such as Raphael Varane, Pepe Reina and Sergi Roberto have already bolstered a promotion-winning squad.
However, Como have come up short in their first competitive contests of 2024-25, following a penalty-shootout defeat to Sampdoria in the Coppa Italia with a chastening reverse on Serie A's opening matchday.
Thiago Motta's new-look Juventus taught them a harsh lesson last week, and after being dealt a 3-0 defeat in Turin they must now try to halt a longstanding trend: Como have failed to win either of their first two matches across 10 Serie A seasons dating back to 1951.
Cagliari Serie A form:
Cagliari form (all competitions):
Como Serie A form:
Team News
Davide Nicola could have a full squad at his disposal this weekend, as Colombian centre-back Yerry Mina returns from suspension and Nadir Zortea may be passed fit after missing Cagliari's Serie A opener.
Even if the latter is available, Paulo Azzi should continue on the hosts' right flank, with Tommaso Augello deployed on the left.
Set to partner Roberto Piccoli up front, Zito Luvumbo will meet the club where he made his first league appearance in Italy, back in September 2021. The Angolan winger was directly involved in more goals than any other Cagliari player last season - four of his own and five assists.
Como's attack will be led by Andrea Belotti, who may have struggled since leaving Torino for Roma but has previously scored eight times against Cagliari in Serie A, playing a part in 13 goals from 14 league games against them.
Like Luvumbo, Alberto Dossena reunites with his former club, having made the most clearances (168 - 92 of which were headed) throughout Italy's top flight last season. Another ex-Cagliari player, Daniele Baselli, may be ruled out by a thigh problem.
Raphael Varane cannot join Dossena in central defence, having suffered a knee injury that will keep the French defender sidelined for several weeks, but Alessio Iovine is back in the fold after serving a one-match ban.
Cagliari possible starting lineup:
Scuffet; Zappa, Mina, Luperto; Azzi, Marin, Prati, Deiola, Augello; Luvumbo, Piccoli
Como possible starting lineup:
Reina; Iovine, Goldaniga, Dossena, Moreno; Braunoder, Engelhardt; Strefezza, Cutrone, Da Cunha; Belotti