The England international sat out the 2-0 midweek win over Luton Town due to a minor flare-up of a previous injury, having already been forced off against Manchester City at the weekend.
However, Saka has been given the green light to come back into the first XI and takes up his usual right-wing position in place of Reiss Nelson, who does not even make the squad on the South Coast.
Saka's return is one of four alterations made by Mikel Arteta for Saturday evening's game, as Gabriel Jesus is also chosen to bomb down the left wing, as Leandro Trossard drops to the bench.
As expected, Declan Rice and Jorginho come back into the midfield triumvirate for Thomas Partey and Emile Smith Rowe, while Ben White makes his 100th Premier League appearance for the Gunners against his former club.
Meanwhile, Brighton boss Roberto De Zerbi has made five alterations from the midweek draw with Brentford, one of which sees Danny Welbeck return to the first XI against his former club in place of Joao Pedro.
Jakub Moder and Julio Enciso are also given the nod in the final third over Facundo Buonanotte and Adam Lallana, while Tariq Lamptey and Pervis Estupinan replace Joel Veltman and Igor Julio out wide.
Brighton & Hove Albion: Verbruggen; Lamptey, Dunk, Van Hecke, Estupinan; Baleba, Gross; Adingra, Moder, Enciso; Welbeck
Subs: Steele, Igor, Pedro, Lallana, Barco, Fati, Veltman, Buonanotte, Peupion
Arsenal: Raya; White, Saliba, Gabriel, Zinchenko; Odegaard, Jorginho, Rice; Saka, Havertz, Jesus
Subs: Ramsdale, Tomiyasu, Kiwior, Partey, Smith Rowe, Vieira, Trossard, Martinelli, Nketiah