Vanderson picked up a milestone yellow card in Brazil's 1-1 draw with Venezuela last time out, and the Monaco defender is therefore suspended for his country's final match of 2024.
Danilo is expected to be the replacement against Uruguay, with the 33-year-old in line to win his 65th cap, but Selecao might otherwise be unchanged for their clash with Marcelo Bielsa's side.
No injuries to the starting side last time out have been reported, although Guilherme Arana has pulled out of the squad with an ankle problem, with Fiorentina's Dodo earning a late call-up.
Alisson Becker, Eder Militao and Rodrygo are among the notable absentees for Brazil, with all three on the sidelines through injury, but Vinicius Junior and Raphinha are available and should start.
There is also expected to be a spot in a wide position for Savinho, while Igor Jesus is set to lead the line.
Jesus has scored once in three appearances for the national side, and the 23-year-old is in line for another start.
Lucas Paqueta and Andreas Pereira are among the options for change in midfield, but it is expected that Gerson and Bruno Guimaraes will again line up as the central two for Dorival Junior's side.
Brazil possible starting lineup: Ederson; Danilo, Marquinhos, Gabriel, Abner; Gerson, Guimaraes; Savinho, Raphinha, Vinicius; I Jesus