The Gunners will leapfrog Manchester City and Liverpool into first place in the top-flight table with victory on the South Coast, which would also mark their 2,000th in the history of the English first division.
Meanwhile, a mediocre start to the 2024-25 season for Bournemouth sees them occupy 13th place in the fledgling rankings, and the Cherries suffered their third defeat in four games just before the international break with a 1-0 loss to Leicester City.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 16
Bournemouth wins: 1
Draws: 2
Arsenal wins: 13
Not until a 1987-88 EFL Cup showdown - which Arsenal won 3-0 before being beaten by Luton Town in the final - did the Gunners lock horns with Bournemouth, and the pair had to wait until 2015 for their maiden battle in the top flight after the Cherries' historic promotion.
As a result, the head-to-head history between Saturday's opponents is relatively modest - they have only crossed paths 16 times in competitive matches down the years, and Arsenal have come up trumps in 13 of them.
In contrast, Bournemouth only have a solitary success to their name against the three-time Premier League winners - a 2-1 home triumph in January 2018 - and another two contests have ended all square, one of which came on Boxing Day 2019 in Arteta's first game as Arsenal manager.
Since that 1-1 stalemate at the Vitality Stadium, the Gunners have conquered Bournemouth five times on the spin across all competitions, easing to a pair of triumphs over the Cherries in the 2023-24 Premier League season by an aggregate scoreline of 7-0.
A 4-0 Vitality Stadium slaughter preceded a 3-0 Emirates victory for Arteta's side in May 2024, although that was nothing in comparison to their battle in North London on March 4, 2023, where Philip Billing scored the second-quickest goal in Premier League history.
A Marcos Senesi header made Arsenal's uphill climb even steeper, but Thomas Partey and Ben White got the Gunners back on terms before Reiss Nelson's heroic 97th-minute winner, which triggered Emirates celebrations like none other.
That 3-2 spectacular was the second of four straight games in which Arsenal have scored at least three times against Bournemouth, who have also never kept a clean sheet in a competitive game against the North London giants.
Last 16 meetings
May 04, 2024: Arsenal 3-0 Bournemouth (Premier League)
Sep 30, 2023: Bournemouth 0-4 Arsenal (Premier League)
Mar 04, 2023: Arsenal 3-2 Bournemouth (Premier League)
Aug 20, 2022: Bournemouth 0-3 Arsenal (Premier League)
Jan 27, 2020: Bournemouth 1-2 Arsenal (FA Cup Fourth Round)
Dec 26, 2019: Bournemouth 1-1 Arsenal (Premier League)
Oct 06, 2019: Arsenal 1-0 Bournemouth (Premier League)
Feb 27, 2019: Arsenal 5-1 Bournemouth (Premier League)
Nov 25, 2018: Bournemouth 1-2 Arsenal (Premier League)
Jan 14, 2018: Bournemouth 2-1 Arsenal (Premier League)
Sep 09, 2017: Arsenal 3-0 Bournemouth (Premier League)
Jan 03, 2017: Bournemouth 3-3 Arsenal (Premier League)
Nov 27, 2016: Arsenal 3-1 Bournemouth (Premier League)
Feb 07, 2016: Bournemouth 0-2 Arsenal (Premier League)
Dec 28, 2015: Arsenal 2-0 Bournemouth (Premier League)
Oct 27, 1987: Arsenal 3-0 Bournemouth (EFL Cup Third Round)
Last 10 Premier League meetings
May 04, 2024: Arsenal 3-0 Bournemouth (Premier League)
Sep 30, 2023: Bournemouth 0-4 Arsenal (Premier League)
Mar 04, 2023: Arsenal 3-2 Bournemouth (Premier League)
Aug 20, 2022: Bournemouth 0-3 Arsenal (Premier League)
Dec 26, 2019: Bournemouth 1-1 Arsenal (Premier League)
Oct 06, 2019: Arsenal 1-0 Bournemouth (Premier League)
Feb 27, 2019: Arsenal 5-1 Bournemouth (Premier League)
Nov 25, 2018: Bournemouth 1-2 Arsenal (Premier League)
Jan 14, 2018: Bournemouth 2-1 Arsenal (Premier League)
Sep 09, 2017: Arsenal 3-0 Bournemouth (Premier League)
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