Having witnessed his side succumb 1-0 to Slovakia at the start of the week, Domenico Tedesco had little choice but to tinker with his starting lineup.
Two of the alterations have come in defence with veteran Jan Vertonghen and Arthur Theate being brought into the backline.
Youri Tielemans is restored to the engine room alongside Amadou Onana, while Dodi Lukebakio will take up a place on the flank.
Zeno Debast, Yannick Carrasco, Orel Mangala and Leandro Trossard are the quartet who have dropped down to the substitutes' bench.
Romania make just one change from Ukraine win
Meanwhile, Romania boss Edward Iordanescu has decided to stick with much of the side that started the comprehensive 3-0 triumph over Ukraine.
The one switch has come on the left flank with Valentin Mihaila taking the spot of Florinel Coman.
Romania will guarantee finishing above Belgium in the Group E standings if they can collect all three points from this contest.
Meanwhile, Belgium will begin the final matchday at the bottom of the group unless they can bounce back from the disappointment of the Slovakia game.
Belgium: Casteels; Castagne, Vertonghen, Faes, Theate; Onana, Tielemans, De Bruyne; Lukebakio, Lukaku, Doku
Subs: Kaminski, Sels, Bakayoko, Carrasco, Debast, De Cuyper, De Ketelaere, Mangala, Openda, Trossard, Vermeeren, Vranckx
Romania: Nita; Ratiu, Dragusin, Burca, Bancu; M.Marin; Man, R.Marin, Stanciu, Mihaila; Dragus
Subs: Moldovan, Tarnovanu, Rus, Nedelcearu, Alibec, Cicaldau, Puscas, Hagi, Olaru, Comon, Mogos, Sorescu, Racovitan, Birligea, Sut