The German giants bested PSV Eindhoven 3-1 on aggregate to reach the last eight, although Nico Schlotterbeck was unavailable for the 2-0 second-leg success, having picked up his third booking of the tournament in the opening fixture.
However, Schlotterbeck has now served his time on the naughty step and is now available for continental duty once more, but the same cannot be said for left-back Ramy Bensebaini, facing weeks out with a nasty knee injury.
As a result, Ian Maatsen should be bombing down the left flank for Dortmund, while Julian Ryerson will likely be given the nod on the right, although Niklas Sule did a competent job there at home to PSV.
With Schlotterbeck returning to the fold, the Germany international should join compatriot Mats Hummels as Gregor Kobel's central barrier, with Emre Can operating just ahead of the duo in the number six role.
Neither Marcel Sabitzer nor Julian Brandt made it to the final 15 minutes of Dortmund's Bundesliga defeat to Stuttgart on Saturday, but the duo should be selected to complement Can in midfield either way.
Up top, Donyell Malen's recent hip setback renders him doubtful for the contest, so an unchanged frontline ought to comprise Jadon Sancho, Karim Adeyemi and Niclas Fullkrug, the latter bidding to end an eight-game scoreless run in all competitions.
Borussia Dortmund possible starting lineup:
Kobel; Ryerson, Hummels, Schlotterbeck, Maatsen; Sabitzer, Can, Brandt; Sancho, Fullkrug, Adeyemi