The Premier League giants head into the game in the West Midlands knowing that victory could secure the club a place in the last 16 of the competition.
Unai Emery hinted at his pre-match press conference that Tyrone Mings may be available, despite concern over a knee injury sustained against West Ham United at the weekend.
However, the centre-back misses out on a place in the squad with Emery making just the one alteration to the team that drew 1-1 with the Hammers.
Lamare Bogarde has been brought into the side, the young Dutchman either being used as a centre-back or in central-midfield. Boubacar Kamara could drop back into defence if it is the latter.
Amid speculation regarding his future, Jhon Duran is only selected among the replacements, Ollie Watkins retaining his place down the middle of the attack.
How many changes have Celtic made?
Meanwhile, Celtic go into this encounter having already sealed a place in the last 24, as well as having a week since their last encounter versus Young Boys.
A total of three alterations have been made by Brendan Rodgers with Liam Scales, Yang Hyun-Jun and Adam Idah being brought into the team.
Aston Villa XI: Martinez; Cash, Konsa, Bogarde, Digne; Bailey, Kamara, Tielemans, Ramsey; Rogers; Watkins
Subs: Duran, Maatsen, McGinn, Nedeljkovic, Olsen, Patterson, Swinkels, Young, Zych
Celtic XI: Schmeichel; Johnston, Trusty, Scales, Taylor; McGregor, Engels, Hatate; Kuhn, Idah, Yang
Subs: Sinisalo, Bain, Palma, McGowan, Nawrocki, Bernardo, Montgomery, Murray, Cummings, Ralston
More to follow.
Written by
Darren Plant