Mikel Arteta and co are hoping that the third time will be the charm this season, having pushed Manchester City in the 2022-23 and 2023-24 title fights only to wind up second best on both occasions.
Meanwhile, their visitors hold top-half aspirations following last season's 14th-placed finish under Gary O'Neil, whose side have a club-worst streak to snap in the English capital this weekend.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 124
Arsenal wins: 64
Draws: 28
Wolves wins: 32
From 124 previous competitive bouts between Arsenal and Wolves, who first did battle back in 1904, the Gunners - as expected - dominate the wins counter with 64, prevailing in just over 50% of their games against the West Midlands side.
In contrast, Wolves have only achieved half of Arsenal's number of victories - 32 - while another 28 battles have ended level, but this head-to-head has been thoroughly dominated by the men in red and white over the past few years.
Indeed, Arsenal have done the double over Wolves in each of the last three Premier League seasons, prevailing 2-1 on home soil and 2-0 at Molineux last season, prior to which they rounded off the 2022-23 term with a 5-0 home crushing; Granit Xhaka scored twice on his farewell appearance.
Nuno Espirito Santo often had the Gunners' number, though, as Wolves won both of their top-flight clashes by a 2-1 scoreline in the 2020-21 season, although the victory at the Emirates was overshadowed by Raul Jimenez's sickening skull fracture.
Wolves' most recent wn in this fixture in February 2021 was clouded in controversy too, as David Luiz and Bernd Leno were both sent off, the former for a perceived last-man foul on Willian Jose inside the area, despite replays showing that the Wolves man had clipped Luiz's knee.
Either way, Arsenal can almost always be backed to make the net bulge against Saturday's visitors, who have astonishingly gone 33 games without a clean sheet against the three-time Premier League winners, a streak stretching all the way back to 1979.
That sequence is both Arsenal's longest scoring run against a single team and Wolves' longest streak without a clean sheet against a particular opponent, and should the Gunners win on Saturday, they would have also beaten Wolves in seven straight Premier League games for the first time.
On a side note, Arsenal and Wolves were the only teams to have an outfield player feature in every minute of the 2023-24 Premier League season - William Saliba and Max Kilman - although the latter has now jumped ship for West Ham United.
Last 20 meetings
Apr 20, 2024: Wolves 0-2 Arsenal (Premier League)
Dec 02, 2023: Arsenal 2-1 Wolves (Premier League)
May 28, 2023: Arsenal 5-0 Wolves (Premier League)
Nov 12, 2022: Wolves 0-2 Arsenal (Premier League)
Feb 24, 2022: Arsenal 2-1 Wolves (Premier League)
Feb 10, 2022: Wolves 0-1 Arsenal (Premier League)
Feb 02, 2021: Wolves 2-1 Arsenal (Premier League)
Nov 29, 2020: Arsenal 1-2 Wolves (Premier League)
Jul 04, 2020: Wolves 0-2 Arsenal (Premier League)
Nov 02, 2019: Arsenal 1-1 Wolves (Premier League)
Apr 24, 2019: Wolves 3-1 Arsenal (Premier League)
Nov 11, 2018: Arsenal 1-1 Wolves (Premier League)
Apr 11, 2012: Wolves 0-3 Arsenal (Premier League)
Dec 27, 2011: Arsenal 1-1 Wolves (Premier League)
Feb 12, 2011: Arsenal 2-0 Wolves (Premier League)
Nov 10, 2010: Wolves 0-2 Arsenal (Premier League)
Apr 03, 2010: Arsenal 1-0 Wolves (Premier League)
Nov 07, 2009: Wolves 1-4 Arsenal (Premier League)
Jan 29. 2005: Arsenal 2-0 Wolves (FA Cup Fourth Round)
Feb 07, 2004: Wolves 1-3 Arsenal (Premier League)
Last 10 Premier League meetings
Apr 20, 2024: Wolves 0-2 Arsenal (Premier League)
Dec 02, 2023: Arsenal 2-1 Wolves (Premier League)
May 28, 2023: Arsenal 5-0 Wolves (Premier League)
Nov 12, 2022: Wolves 0-2 Arsenal (Premier League)
Feb 24, 2022: Arsenal 2-1 Wolves (Premier League)
Feb 10, 2022: Wolves 0-1 Arsenal (Premier League)
Feb 02, 2021: Wolves 2-1 Arsenal (Premier League)
Nov 29, 2020: Arsenal 1-2 Wolves (Premier League)
Jul 04, 2020: Wolves 0-2 Arsenal (Premier League)
Nov 02, 2019: Arsenal 1-1 Wolves (Premier League)
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