Mikel Arteta's men have eliminated two lower-tier sides in Bolton Wanderers and Preston North End to progress this far, while the Eagles have managed to see off Norwich City, Queens Park Rangers and Aston Villa in the earlier rounds.
However, only one came up trumps at the weekend, as while the Gunners laboured to a 0-0 draw in their Premier League showdown with Everton, Oliver Glasner's side soared to a brilliant 3-1 win over Brighton & Hove Albion in the so-called M23 derby.
Here, Sports Mole takes an in-depth look at the head-to-head record and previous meetings between the two sides.
Head-to-head record
Previous meetings: 55
Arsenal wins: 33
Draws: 16
Crystal Palace wins: 6
Not the most common London derby on the in the annals of English football, Arsenal and Crystal Palace have only ever done battle on 55 occasions, and the Gunners have dominated their capital counterparts more often than not.
Indeed, the three-time Premier League winners have beaten the Eagles on 33 occasions while only suffering six defeats, and 16 stalemates have also been played out between the two near neighbours.
Heading into Wednesday's quarter-final contest with Crystal Palace, Arsenal are searching for a fifth successive win over the Eagles, whom they did the double over in both the 2022-23 and 2023-24 Premier League campaigns.
Gabriel and Gabriel Martinelli both struck braces in a 5-0 London derby drubbing at the Emirates in January 2024, prior to which a 10-man Arsenal left Selhurst Park with a 1-0 success in August 2023 despite losing Takehiro Tomiyasu to a second bookable offence.
The Gunners also conquered Palace by an aggregate score of 6-1 over their two meetings in 2022-23, prior to which the Eagles ripped Mikel Arteta's team to shreds in a 3-0 Selhurst Park triumph in August 2022, their most recent victory in this battle.
A Patrick Vieira-led Palace side were also on the verge of leaving the Emirates with a 2-1 win in October 2021, only for Alexandre Lacazette to come up with a last-gasp equaliser for the Gunners, who have lost just one of their last 10 meetings with the Eagles.
However, Arsenal went winless in five straight games against Palace from October 2018 to January 2021, a run that included a 2-3 home defeat in April 2019, the Eagles' first and only victory at the Emirates Stadium to date.
No player was more fond of a goal in Arsenal vs. Crystal Palace than ex-Gunner John Radford, who netted eight times in this head-to-head, while Alan Smith and Paul Merson managed six goals each for Arsenal against the Eagles.
Last 20 meetings
Jan 20, 2024: Arsenal 5-0 Crystal Palace (Premier League)
Aug 21, 2023: Crystal Palace 0-1 Arsenal (Premier League)
Mar 19, 2023: Arsenal 4-1 Crystal Palace (Premier League)
Aug 05, 2022: Crystal Palace 0-2 Arsenal (Premier League)
Apr 04, 2022: Crystal Palace 3-0 Arsenal (Premier League)
Oct 18, 2021: Arsenal 2-2 Crystal Palace (Premier League)
May 19, 2021: Crystal Palace 1-3 Arsenal (Premier League)
Jan 14, 2021: Arsenal 0-0 Crystal Palace (Premier League)
Jan 11, 2020: Crystal Palace 1-1 Arsenal (Premier League)
Oct 27, 2019: Arsenal 2-2 Crystal Palace (Premier League)
Apr 21, 2019: Arsenal 2-3 Crystal Palace (Premier League)
Oct 28, 2018: Crystal Palace 2-2 Arsenal (Premier League)
Jan 20, 2018: Arsenal 4-1 Crystal Palace (Premier League)
Dec 28, 2017: Crystal Palace 2-3 Arsenal (Premier League)
Apr 10, 2017: Crystal Palace 3-0 Arsenal (Premier League)
Jan 01, 2017: Arsenal 2-0 Crystal Palace (Premier League)
Apr 17, 2016: Arsenal 1-1 Crystal Palace (Premier League)
Aug 16, 2015: Crystal Palace 1-2 Arsenal (Premier League)
Feb 21, 2015: Crystal Palace 1-2 Arsenal (Premier League)
Aug 16, 2014: Arsenal 2-1 Crystal Palace (Premier League)
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Written by
Ben Knapton