The Dutchman suffered his first competitive defeat as Reds manager on Saturday, where Nottingham Forest shocked the Merseyside giants 1-0 at Anfield as Liverpool were left to rue their worrying wastefulness in front of goal.
Slot has kept faith in the Mohamed Salah-Diogo Jota-Luis Diaz trident throughout the Premier League season so far, but with just two full days to recover, the former Feyenoord boss should now turn to the bench.
It remains to be seen whether Federico Chiesa will finally make his debut on Tuesday, having been left out of the squad for the Forest defeat due to his fitness levels, but Cody Gakpo and Darwin Nunez are both viable options for change.
Neither man made a positive impact as substitutes on Saturday, but they should come into consideration to replace Diaz and Jota regardless, as Salah and Dominik Szoboszlai continue in the final third.
Alexis Mac Allister played just over an hour against Forest, but after his knock on international duty, Slot may wish to introduce Wataru Endo, giving Ryan Gravenberch licence to play a bit further up the field; Harvey Elliott (foot) is a long-term absentee.
However, the backline of Alisson Becker, Virgil van Dijk, Ibrahima Konate, Andrew Robertson and Trent Alexander-Arnold should remain untouched, although the latter will have the unenviable job of keeping Rafael Leao in check.
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Endo, Gravenberch; Salah, Szoboszlai, Gakpo; Nunez