The Reds are making their swift return to the top level of continental competition thanks to their third-placed finish in last year's Premier League, and the trip to Italy will see Arne Slot take charge of a continental game for the first time as Liverpool head coach.
The Dutchman's team have some wrongs to right from the weekend's Premier League action, though, having suffered a shock 1-0 loss to Nottingham Forest at Anfield to end their 100% start to the season.
Here, Sports Mole rounds up all of Liverpool's latest injury and suspension news ahead of their clash with the Rossoneri, who thumped Venezia 4-0 in Serie A action over the weekend.
Harvey Elliott
Status: Out
Type of injury: Foot
Possible return date: October 27 (vs. Arsenal)
The sole long-term absentee in Liverpool's ranks, Harvey Elliott was revealed to have sustained a foot fracture while on international duty this month, and he will not be back in action for at least six weeks.
Federico Chiesa
Status: Major doubt
Type of injury: Fitness
Possible return date: September 17 (vs. Milan)
Still waiting for his debut in Liverpool red, new signing Federico Chiesa did not make the squad to make Forest as he builds his fitness back up, and the quick turnaround makes him a huge doubt for the trip to his homeland too.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no players suspended for this match.