Jakub Plsek (born 13 December 1993) is a professional Czech football midfielder currently playing for Puskas Akademia FC in the Nemzeti Bajnoksag I.
He made his league debut on 6 October 2012 in a 1–0 Czech First League away win at FK Mlada Boleslav, against whom he also scored his first league goal on 21 April 2013. On 18 October 2016, he scored five goals in a Czech National Football League 7–0 home rout of Prostejov. He finished the 2016–17 National Football League season with a tally of 18 goals in 28 matches, becoming the league's top scorer. He won the Czech National Football League Best Player award in 2017.