The Cottagers' three-game winning run came to an end in Saturday's 2-0 loss to Crystal Palace, where Emile Smith Rowe hurt his ankle and substitute Tom Cairney also suffered an unspecified injury.
Silva could not say how severe their issues were at full time, but the short turnaround makes it difficult to envisage them making rapid recoveries in time for the trip to the West Midlands.
As a result, Andreas Pereira should act as the creative focal point in an otherwise unaltered attacking setup, as Alex Iwobi and Adama Traore also support ex-Wolves striker Raul Jimenez.
Cairney's blow will not impact the established midfield pairing of Sander Berge and Sasa Lukic, while Timothy Castagne and Antonee Robinson should be shoo-ins in the full-back areas once more.
Joachim Andersen endured a nightmare afternoon against his old team on Saturday, turning a Will Hughes corner into his own net for Palace's first, but the Dane is still expected to link arms with Calvin Bassey as Bernd Leno's central shield.
Harry Wilson (foot), Kenny Tete (knee) and Reiss Nelson (hamstring) are all out of contention for the Cottagers, who might be missing the latter for the rest of the season following his operation.
Fulham possible starting lineup:
Leno; Castagne, Andersen, Bassey, Robinson; Berge, Lukic; Traore, Pereira, Iwobi; Jimenez
Written by
Ben Knapton