Meanwhile, the relegation-threatened visitors will be hoping to boost their survival hopes by ending their seven-game winless run.
Match preview
Wigan have experienced mixed fortunes in recent weeks, winning three consecutive home matches and losing three of their last four away games.
In their most recent outing, the Latics recorded a narrow 1-0 home win over Blackpool thanks to Scott Smith's 26th-minute effort.
Wigan are sitting in a midtable position with seven matches left to play, but they would be within five points of the playoffs were it not for an eight-point deduction,
While a top-six push may be out of the question, the 12th-placed Latics will still be keen to finish the season with a strong run of form, beginning with Saturday's home fixture against Burton.
Having failed to win either of their last two head-to-head meetings, Wigan are looking to beat the Brewers for the first time since October 2021.
Burton are languishing in 19th position and just three points above the drop zone after losing six of their last seven matches (D1).
Martin Paterson's side fell to a fourth consecutive defeat in last Saturday's home meeting with Port Vale, losing 1-0 following a late Ryan Loft strike.
Having failed to score in five of their previous seven games, Burton need to find a cutting edge in the final third if they are to maintain their League One status.
The Brewers managed to find the net in October's reverse fixture against Wigan, with Joe Powell scoring a brace in a 2-1 home victory.
However, Burton have failed to win any of their last three head-to-head away meetings since recording a 1-0 victory in November 2015.
Wigan Athletic League One form:
D
W
L
W
L
W
Burton Albion League One form:
L
D
L
L
L
L
Team News
The hosts are unable to call upon midfielder Chris Sze, who sustained an injury in the defeat to Wycombe earlier this month.
Winger Callum McManaman is also unlikely to feature, having missed the last two matches due to an injury issue.
Wigan boss Shaun Maloney could be tempted to select the same lineup that started the narrow win over Blackpool a couple of weeks ago.
Burton, meanwhile, are still expected to be without the services of defender Jasper Moon, who has been out of action since the start of February.
Goalkeeper Max Crocombe missed the defeat to Port Vale due to international duty, but he is expected to return to the starting lineup for Saturday's contest.
Mason Bennett could return to his place in the side after returning from injury to play over an hour against the Valiants.
Wigan Athletic possible starting lineup:
Tickle; Smith, Hughes, Kerr, Chambers; M Smith, Adeeko; Godo, Aasgaard, Jones; Humphrys
Burton Albion possible starting lineup:
Crocombe; Hamer, Nsiala, Sweeney, Brayford, Seddon; Oshilaja, Powell, Helm; Bennett, Hugill