For instance, defender Yerson Mosquera underwent knee surgery in October and there is currently no timeframe on when he could return to action.
Elsewhere, striker Sasa Kalajdzic is said to have returned to training on grass on October 18, but he is still not expected back for several weeks, while attacker Enso Gonzalez Medina's knee injury could keep him out of the XI for months.
Considering the absences in attack, Wolves could select a forward line consisting of Pablo Sarabia, Matheus Cunha and Hee-Chan Hwang against West Ham United on Monday night.
Full-back Nelson Semedo is suspended due to the fact he has accumulated five yellow cards, so expect Matt Doherty and Rayan Ait-Nouri play on the right and left of a back four respectively.
The full-backs may flank centre-backs Toti Gomes and Craig Dawson, who are likely to be asked to protect goalkeeper Daniel Bentley.
In midfield, O'Neil could start Tommy Doyle, Mario Lemina and Jean-Ricner Bellegarde in the middle of the pitch.
Wolverhampton Wanderers possible starting lineup: Bentley; Doherty, Gomes, Dawson, Ait-Nouri; Doyle, Lemina, Bellegarde; Sarabia, Cunha, Hwang
Written by
Lewis Nolan