The Bees have had plenty of time to prepare for their short trip to the London Stadium after they had a free weekend due to January's FA Cup defeat to Plymouth Argyle.
Brentford will enter Saturday's fixture in 11th place in the Premier League table after collecting 31 points from 24 matches.
The Bees are looking to win three consecutive top-flight games for the first time in their history after beating Southampton and Crystal Palace in their last two road trips.
Brentford handed Flekken boost
Frank has confirmed the positive news that Flekken will be available for selection after missing the 2-0 home loss against Tottenham Hotspur with a side strain.
"The same players are available from the last game. Mark Flekken is ready and will be in goal, which is good," Frank told reporters in Friday's pre-match conference.
The former Freiburg goalkeeper will replace his deputy Hakon Valdimarsson, who made his second Premier League appearance in the defeat to Tottenham.
While Brentford will be able to call upon Flekken's services, they remain without the injured Josh Dasilva, Rico Henry, Gustavo Nunes and Igor Thiago.
What is the latest on Hickey's recovery?
Hickey is another player who is unavailable for selection, having been out of action since October 2023 due to a serious hamstring injury.
While a return to action is not imminent, Frank has confirmed that Hickey has stepped up his recovery with a return to full training.
"He is training with the first team in parts, and is planning to be in full training next week with the team," Frank added.
"He has been out for 16 months. I will be happy the day he is involved in the squad, more happy when he comes on the pitch, and even more happy when he is starting a game, but when has been out for so long I don't want to be too excited before he is really ready. From next week he needs a pre-season."
It was also recently reported that Thiago will hope to return to action after the international break following his struggles with a knee injury.
Written by
Ben Sully
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