The Catalan side are top of the table on 15 points, while a strong start for Villarreal has seen them collect 11 points to sit fourth, and here Sports Mole rounds up the team news for the two sides.
VILLARREAL vs. BARCELONA
VILLARREAL
Out: Willy Kambwala (muscle), Gerard Moreno (hamstring), Juan Foyth (knee), Alfonso Pedraza (ligament)
Doubtful: None
Sports Mole's predicted XI: Conde; Femenia, Albiol, Costa, S Cardona; Akhomach, Comesana, Parejo, Baena; Perez, Barry
BARCELONA
Out: Ferran Torres (suspension), Fermin Lopez (thigh), Dani Olmo (hamstring), Marc Bernal (knee), Andreas Christensen (Achilles), Ronald Araujo (hamstring), Frenkie de Jong (ankle), Gavi (knee)
Doubtful: None
Sports Mole's predicted XI: Ter Stegen; Kounde, Cubarsi, I Martinez, Balde; Casado, E Garcia, Pedri; Yamal, Lewandowski, Raphinha
For data analysis of the most likely results, scorelines and more for this match please click here.