The visitors are currently propping up the standings with one point to their name, while Suriname are three points better off in third position.
Match preview
Having collected four points from three matches, Suriname are sitting one point adrift of the top two and one point above the relegation zone.
Suriname began their 2024-25 Nations League campaign with a 3-1 away win over Guyana, before they fell to a narrow 1-0 defeat in their trip to Guadeloupe on matchday two.
Stanley Menzo's side returned to action in Friday's home clash against Costa Rica, with Gleofilo Vlijter scoring a 34th-minute equaliser to cancel out Josimar Alcocer's opener.
Suriname played the majority of the second period with an extra player following Alcocer's 51st-minute red card, but they ultimately failed to make most of the numerical advantage as they played out a draw for the third time in their last five Nations League home games.
With everything to play for on matchday four, Tuesday's visitors may be able to take confidence from the fact they have won three of their previous five head-to-head matches in regulation time.
Meanwhile, Guyana are still searching for the first win of their Nations League campaign after drawing one and losing two of their three matches.
Guyana fell to a 3-1 home defeat in their opening game against Suriname, before they gave up a two-goal lead to draw 2-2 in their away meeting with Martinique.
They then slumped to a 3-1 loss in Friday's home fixture against Guatemala despite going into the break on level terms following Stephen Duke-McKenna's 31st-minute equaliser.
Having conceded eight goals in three matches, Guyana head into the final group game with the worst defensive record in League A, highlighting a key area for improvement if they are to claim a positive result in their meeting with Suriname.
While their fate is out of their hands, Jamaal Shabazz's side can give themselves the best possible chance of avoiding relegation if they can beat Suriname for the first time since winning 2-0 in a friendly in February 2016.
Suriname CONCACAF Nations League form:
W
L
D
Suriname form (all competitions):
D
W
W
W
L
D
Guyana CONCACAF Nations League form:
L
D
L
Guyana form (all competitions):
L
L
W
L
D
L
Team News
Menzo may decide to opt for consistency and select the same Suriname side that started the recent 1-1 draw against Costa Rica.
After providing an assist on Friday, Real Sociedad's Sheraldo Becker will continue to offer one of his country's main attacking threats when he makes his 14th international appearance on Tuesday.
OFK Beograd's Vlijter will continue to lead the line for Suriname, with the striker looking to continue his fine form after scoring four goals in his last four matches for club and country.
As for the visitors, they will have to assess the fitness of Terence Vancooten and Ryan Hackett after they were forced off in the second half against Guatemala.
Reiss Greenidge and Nathan Ferguson could be handed starting roles if Vancooten and Hackett are unable to play a part in Tuesday's fixture.
Suriname possible starting lineup:
Hahn;; Dijksteel, Van Gelderen, Pinas, Haps; Paal, Malone; Van der Kust, Pherai, Becker; Vlijter
Guyana possible starting lineup:
Roberts; Lovell, Greenridge, J. Jones, Nelson; Ferguson, Duke-McKenna; I. Jones, Moriah-Welsh, Gordon; Glasgow