Ange Postecoglou's men relegated Burnley on Saturday courtesy of a 2-1 come-from-behind triumph, thereby keeping their top-four hopes alive until Monday night at the very least.
However, Richarlison - omitted from the Brazil squad for the 2024 Copa America - missed that victory due to a calf issue sustained in training, one that is not expected to settle down in time for this contest.
The attacker joins Timo Werner (hamstring), Ben Davies (calf), Manor Solomon (knee), Ryan Sessegnon (thigh), Fraser Forster (ankle) and Destiny Udogie (thigh) in the hosts' medical bay, leaving Postecoglou short of options for change up top.
Consequently, the quarter of James Maddison, Son Heung-min, Dejan Kulusevski and Brennan Johnson should all reprise their roles up front, unless Postecoglou springs a surprise by promoting Bryan Gil or Giovani Lo Celso.
The tight turnaround and Postecoglou's nature to exercise caution over his players means that there is scope for a midfield alteration, though; Rodrigo Bentancur may displace Pape Sarr to partner Yves Bissouma.
The Australian's biggest quandary is undeniably at left-back, though, as Emerson Royal ceded his spot to Oliver Skipp on Saturday, and match-winner Micky van de Ven completed the match in that position, with Radu Dragusin occupying a central role.
However, Skipp has not had many minutes in his legs recently, and Postecoglou said after the game that Van de Ven's fitness troubles makes him reluctant to deploy him out wide, so Emerson can potentially look forward to a recall alongside Cristian Romero, Pedro Porro and Guglielmo Vicario.
Tottenham Hotspur possible starting lineup:
Vicario; Porro, Romero, Van de Ven, Emerson; Bissouma, Bentancur; Kulusevski, Maddison, Johnson; Son