Ange Postecoglou's side entered the two-week pause on the back of a dismal 3-0 loss to London rivals Fulham, where Rodrigo Muniz struck twice either side of a Sasa Lukic effort at Craven Cottage.
Spurs' crushing defeat to the Cottagers saw them miss the chance to rise into the top four of the Premier League table, meaning that the Lilywhites remain fifth with 10 matches to go, albeit just three points behind Aston Villa with a game in hand.
Here, Sports Mole rounds up Tottenham's latest injury and suspension news ahead of their clash with the Hatters, who have been promoted to 17th thanks to Nottingham Forest's points deduction.
Micky van de Ven
Status: Minor doubt
Type of injury: Thigh
Possible return date: March 30 (vs. Luton Town)
Owing to the thigh injury he sustained against Aston Villa earlier this month, Micky van de Ven was unavailable for the loss to Fulham and the Netherlands' international fixtures, but there is optimism that he will be given the all-clear to face Luton.
Fraser Forster
Status: Out
Type of injury: Foot
Possible return date: Unknown
Second-choice goalkeeper Fraser Forster has been ruled out for a couple of months with the foot fracture he sustained in February, meaning that he should not be at Postecoglou's disposal again until the end of April.
Manor Solomon
Status: Out
Type of injury: Knee
Possible return date: Unknown
Manor Solomon's knee injury is proving incredibly difficult for the winger to overcome, and he underwent another operation during the international break, further prolonging his wait for a comeback.
Ryan Sessegnon
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Ryan Sessegnon had only just battled back from one hamstring problem before picking up another similarly severe injury, and the Englishman is expected to miss the rest of the season after also going under the knife.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Tottenham have no players suspended for this match.