The Dane has been struggling with a calf problem since the 4-1 defeat to Wolverhampton Wanderers last weekend, and Silva has now admitted that he will be out for the next few matches.
Harrison Reed (knee) welcomes Andersen into the Fulham infirmary, while Jorge Cuenca and one-time Tottenham man Ryan Sessegnon are both touch-and-go for the all-capital clash.
With Andersen missing, Issa Diop should be introduced into an otherwise untouched backline, as Calvin Bassey, Kenny Tete and Antonee Robinson protect former Arsenal goalkeeper Bernd Leno as ever.
Sander Berge was absent from loss to Wolves on account of his own knock, but the Norwegian will presumably be OK to line up alongside Andreas Pereira in the middle here, thus bumping Sasa Lukic down to the bench.
An all-Hale End trio of Alex Iwobi, Reiss Nelson and Emile Smith Rowe supported Raul Jimenez against Wolves, but both Adama Traore and Harry Wilson will threaten Nelson's place in the side.
Fulham possible starting lineup:
Leno; Tete, Diop, Bassey, Robinson; Berge, Pereira; Traore, Smith Rowe, Iwobi; Jimenez
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