Cristian Romero, Micky Van de Ven, Rodrigo Bentancur and Giovani Lo Celso were all pictured returning to training earlier this week after enjoying an extended summer break and the quartet could be in contention to feature in some capacity against Bayern.
However, Spurs will be without striker Richarlison, who is yet to earn any pre-season minutes as he continues to work his way back from a long-term calf injury, and the same can be said for left-back Destiny Udogie who has been sidelined since undergoing thigh surgery at the end of April.
Young centre-back Ashley Phillips is doubtful after missing Tottenham's 2-1 loss to Bayern last weekend, while forward Alejo Veliz has completed a loan move to Espanyol.
Following a jaded display in their first match against Bayern, Ange Postecoglou is expected to rotate his side throughout the 90 minutes, although a front four of captain Son Heung-min, Dejan Kulusevski, Brennan Johnson and James Maddison could remain intact from the off.
New signings Archie Gray and Lucas Bergvall have both featured regularly in pre-season and are set to get more minutes under their belts on Saturday, while other youngsters including highly-rated winger Mikey Moore could also be given a run-out.
Tottenham Hotspur possible starting lineup: Vicario; Porro, Romero, Dragusin, Davies; Bissouma, Sarr; Kulusevski, Maddison, Johnson; Son