Ange Postecoglou's side recovered from their capitulation by beating West Ham United 4-1 on Saturday, and they are one of just five teams who have won their opening two Europa League games this season.
For visitors AZ Alkmaar, they come into the clash having lost four straight games in all competitions, their worst streak since 2002, placing manager Maarten Martens under some pressure.
Here, Sports Mole rounds up all of Spurs' latest injury and suspension news ahead of the clash with the Dutch side at the Tottenham Hotspur Stadium.
Djed Spence
Status: Out
Type of injury: Groin
Possible return date: October 27 (vs. Crystal Palace)
Not long after signing a new contract at the club, Spence missed out on the 4-1 win over West Ham at the weekend, with manager Postecoglou confirming he suffered a groin strain ahead of the encounter.
Wilson Odobert
Status: Out
Type of injury: Hamstring
Possible return date: October 27 (vs. Crystal Palace)
During Tottenham's EFL Cup win over Coventry City in September, Odobert sustained a hamstring injury subsequently missing the following six games, and the ex-Burnley man is not yet ready for a return to the starting XI.
TOTTENHAM'S SUSPENSION LIST
Spurs have no players who are suspended for this Europa League outing after Radu Dragusin served a one-match ban in the matchday two win over Ferencvaros.
Reims 
Lyon 
PSV 
Groningen 
Celta Vigo 
Barcelona 
Benfica 
Estrela Da Amadora 
Sparta Rotterdam 
AZ Alkmaar 
Southampton 
Liverpool 
Como 
Fiorentina 
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund