La Roja secured top spot in Group 4 of League A on Friday night courtesy of a 2-1 success over Denmark, with the European champions advancing to the quarter-finals as section winners.
Switzerland will finish bottom of the group, meanwhile, so there is nothing substantial to play for on Monday, meaning that De la Fuente will shuffle his pack.
Spain have released Martin Zubimendi, Alex Baena and Mikel Oyarzabal from their squad for this match, although the latter would have missed out regardless through suspension; Pablo Barrios has been handed a call-up, with the Atletico Madrid midfielder pushing to make his debut.
The same can also be said for Samu Omorodion, who has scored 12 times in 13 appearances for Porto this season, and the youngster is expected to be handed his international debut off the bench.
Pau Cubarsi, Bryan Gil and Bryan Zaragoza were all left out of the squad against Denmark but are set to be available here, while Nico Williams and Alvaro Morata are in line for starts.
Williams was a 70th-minute substitute against Denmark, while Morata was introduced in the 69th minute, with the captain not starting due to slight concerns over a head injury which he suffered during a recent training session with AC Milan.
Fabian Ruiz, Oscar Mingueza, Alex Grimaldo and Yeremy Pino could also potentially be introduced into the XI.
Spain possible starting lineup: Raya; Mingueza, Vivian, Laporte, Grimaldo; Merino, Ruiz; N Williams, Olmo, Pino; Morata