When these sides met a week ago, neither could find that decisive breakthrough, playing to a 0-0 draw at Estadio Nilton Santos.
Match preview
We saw another sound defensive performance from Sao Paulo in the opening leg of this tie last week, maintaining a seventh clean sheet in nine Libertadores encounters this year.
Luis Zubeldia's men have yet to concede a goal at home in this competition, going unbeaten at Morumbi in their four Libertadores contests played there this year.
Sao Paulo have not made the Copa Libertadores semi-finals since 2016, falling to Atletico Nacional at that stage, 4-1 on aggregate.
Their last two home matches across all competitions have ended in defeat, with Soberano losing 3-1 to Internacional domestically this past weekend.
They have not lost consecutive competitive fixtures across all competitions since following up a 1-0 defeat to Atletico Mineiro in late August with a 2-0 loss at Fluminense at the beginning of this month.
Tricolor Paulista have not lost a quarter-final home fixture in the Libertadores since Cruzeiro beat them in this round, 2-0, back in 2009.
The knockout portion of this tournament has proven to be quite challenging for the current Brasileiro Serie A leaders Botafogo, who failed to win last week for the third time in their previous four matches at this tournament.
While they have not conceded in three successive Libertadores affairs, Artur Jorge's men have only netted one goal over that stretch.
Their current unbeaten run sits at eight matches across all competitions, following a 1-0 victory over Fluminense on Sunday, putting them three points clear of Palmeiras at the top of the Brasileiro Serie A table.
Fogo have only suffered one defeat away from home at the Libertadores this year (1-0 versus LDU Quito), winning only once as the visitors in this competition (1-0 over Universitario).
You have to go back to 1963 for the previous time they made the semi-finals of this tournament, losing their last Libertadores quarter-final tie to Gremio in 2017, 1-0 on aggregate after the opener ended in a 0-0 draw.
O Glorioso are unbeaten in their last seven matches versus Sao Paulo across all competitions, with their previous victory at Morumbi occurring in the 2022 top-flight campaign (1-0).
Sao Paulo Copa Libertadores form:
W
D
W
D
W
D
Sao Paulo form (all competitions):
L
L
D
W
D
L
Botafogo Copa Libertadores form:
W
W
D
W
D
D
Botafogo form (all competitions):
Team News
A trio of players will probably be sidelined for Sao Paulo on Wednesday, as Pablo Maia, Ferreira and Moreira are all dealing with thigh injuries.
Alisson will miss this encounter due to a broken ankle, and Patryck continues to recover from a shoulder injury, which will likely keep him out until early October.
Jonathan Calleri leads them with four goals at the Libertadores this year, while Rafael made six saves in the opening leg to collect his sixth clean sheet of the tournament.
In the opening game of this tie, thigh injuries kept Matheus Nascimento, Pablo, and Cuiabano on the sidelines and neither are expected to feature in this match.
Rafael da Silva and Jeffinho will probably miss this upcoming fixture as well because of knee injuries, with an expected return in early October.
John only had to make one stop between the sticks in leg one of this tie, collecting his third clean sheet of the Libertadores this year, while Junior Santos remains on top of the goalscoring table, with nine in the competition.
Sao Paulo possible starting lineup:
Rafael; Franco, Arboleda, Sabino; Araujo, Bobadilla, Gustavo, Welington; Luciano, Gomes; Calleri
Botafogo possible starting lineup:
John; Vitinho, Bastos, Barboza, Telles; Gregore, Freitas; Soares, Savarino, Almada; Santos
We say: Sao Paulo 0-1 Botafogo (Botafogo advances 1-0 on aggregate)
Fogo have won countless one-goal games in the Brazilian top-flight this season, and we trust their consistency against Brasileiro opposition will continue in midweek and carry them into the final four of this tournament.