Hansi Flick's side enter this contest on the back of beating Catalan rival Espanyol 3-1 in La Liga and they have subsequently moved nine points clear at the top of the table.
In the Champions League, Barcelona have picked up six points from a possible nine available and will be hoping to build on their impressive 4-1 victory over Bayern Munich on matchday three a fortnight ago.
Ahead of Barca's encounter with Red Star, Sports Mole rounds up their latest injury and suspension news.
Marc-Andre ter Stegen
Status: Out
Type of injury: Knee
Possible return date: Unknown
Barcelona's first-choice goalkeeper Ter Stegen will miss the rest of the season with a serious knee injury sustained in the La Liga clash with Villarreal on September 22.
Marc Bernal
Status: Out
Type of injury: Knee
Possible return date: Unknown
Bernal suffered an ACL injury against Rayo Vallecano in August and the teenage midfielder is ruled out for the rest of the season.
Eric Garcia
Status: Out
Type of injury: Muscle
Possible return date: November 23 (vs. Celta Vigo)
Garcia has missed Barcelona's last four matches with a muscle injury and the defender is targeting a return to action after this month's international break.
Ronald Araujo
Status: Out
Type of injury: Hamstring
Possible return date: November 26 (vs. Brest)
Araujo is making progress in his recovery from hamstring surgery, but the centre-back is not expected to return until the end of the month.
Andreas Christensen
Status: Major doubt
Type of injury: Achilles
Possible return date: November 10 (vs. Real Sociedad)
Christensen is in the latter stages of his recovery from an Achilles injury and the defender may be fit to return before this month's international break, but Wednesday's game will likely come too soon for the Dane.
Ferran Torres
Status: Major doubt
Type of injury: Thigh
Possible return date: November 10 (vs. Real Sociedad)
Torres has missed Barcelona's last four games with a thigh injury and it remains to be seen whether he will be fit to return before the international break.
BARCELONA'S SUSPENSION LIST
Barcelona have no suspended players for this match.