There had been concerns over the duo's fitness following Wednesday's 2-0 defeat to Liverpool in the Champions League, but the pair are available this weekend, while the same can also be said for Brahim Diaz, who also emerged as a doubt due to an unspecified problem after the European clash in England.
Real Madrid will definitely be without the services of Vinicius Junior, Eduardo Camavinga, Eder Militao, Dani Carvajal and David Alaba for this weekend's contest in the Spanish capital, but the capital side could have a double fitness boost.
Aurelien Tchouameni and Rodrygo could be back in the squad after recent issues, although the pair are unlikely to start, with positions on the bench more likely here.
Lucas Vazquez is expected to return to the side at right-back, which would see Federico Valverde move back into midfield, while Dani Ceballos could be introduced in the middle, with Luka Modric likely to drop out.
There may also make a change at left-back, with Fran Garcia potentially replacing Ferland Mendy, but Raul Asencio is set to continue in the middle of the defence alongside Antonio Rudiger.
Arda Guler and Diaz both started against Liverpool, and the pair are likely to retain their spots, with Mbappe set to feature through the middle despite largely struggling in that position during the 2024-25 campaign.
Real Madrid possible starting lineup: Courtois; Vazquez, Rudiger, Asencio, F Garcia; Ceballos, Valverde, Bellingham; Guler, Mbappe, Diaz