The 20-year-old is on loan at Getafe from Real Madrid, and he scored his first goal for his loan side against Real Valladolid last weekend, before providing an assist against Manises in the Copa del Rey earlier this week.
Rodriguez is eligible to take on his parent club, and with Borja Mayoral a major doubt to face his former team due to a muscular problem, it is likely that the former will start through the middle.
Getafe's options in the final third of the field are further limited by the fact that Bertug Yildirim is suspended, with the 22-year-old picking up a milestone yellow card against Real Valladolid.
Djene Dakonam was booked in the same match and will be suspended for the same reason, while Carles Alena is also unavailable for selection due to a muscular problem.
There are not expected to be any major surprises in the Getafe side this weekend considering the squad that will be available, and there is again set to be another start for Christantus Uche, who is believed to have attracted the attention of Chelsea this season due to his strong form since arriving in Spain's top flight.
Getafe possible starting lineup: Soria; Iglesias, Duarte, Alderete, Rico; Milla, Arambarri; Nyom, Uche, Perez; Rodriguez