The Blue and Whites will enter the contest at Bernabeu off the back of a 2-1 win over Sevilla, with Carlos Vicente and Carlos Martin on the scoresheet.
Kike Garcia will be firmly in Garcia's thoughts when it comes to potential changes, but Toni Martinez has scored twice in La Liga this season, and the latter should continue in the final third of the field.
Jesus Owono remains on the sidelines through injury, but Alaves are otherwise in excellent shape, with head coach Garcia having a strong squad to choose from.
It is once again expected to be a 4-2-3-1 formation for Alaves in the Spanish capital, with Stoichkov also set to keep hold of his spot in the final third of the field.
There are options for change in midfield, but Joan Jordan and Ander Guevara should continue in that area, while Manu Sanchez is a key player for the team at left-back.
Jon Guridi and Antonio Blanco should be among those on the bench on Tuesday night.
Alaves possible starting lineup: Sivera; Tenaglia, Abqar, Sedlar, M Sanchez; Jordan, Guevara; Vicente, Stoichkov, Martin; T Martinez