Marco Rose's team have already been bested by Juventus and Atletico Madrid in the current campaign, but they have won their last two in the Bundesliga against Heidenheim and most recently Mainz 05.
Striker Lois Openda and midfielder Amadou Haidara sustained knocks in that match, but both men are optimistic of recovering in time for the midweek affair, where the former will help to comprise a mean-looking attack.
Openda ought to form a two-man strikeforce with Benjamin Sesko, scorer of all three of Leipzig's goals in the current Champions League campaign, while Dutch maestro Xavi Simons pulls the strings in the number 10 slot.
Haidara's quick return to fitness will see the Mali midfielder join forces with Atletico loanee Arthur Vermeeren in the centre, as Antonio Nusa and Lutsharel Geertruida - a former stalwart of Arne Slot's Feyenoord - bomb down the flanks.
Reunions are also in store in defence, as ex-Liverpool goalkeeper Peter Gulacsi takes on his erstwhile club, and the Hungarian should be shielded by Castello Lukeba and the long-serving Lukas Klostermann and Willi Orban.
Xaver Schlager (ACL), David Raum (ligament), Nicolas Seiwald (groin) and Assan Ouedraogo (knee) are all out of Wednesday's game through injury for the hosts.
RB Leipzig possible starting lineup:
Gulacsi; Orban, Klostermann, Lukeba; Geertruida, Haidara, Vermeeren, Nusa; Simons; Sesko, Openda