Gustavo Alfaro's men remain outside the coveted top six places after a goalless draw with Ecuador last time out, while their visitors lie in the inter-confederation playoff spot after a creditable 1-1 stalemate versus Argentina.
Match preview
Without a World Cup appearance since making it to the quarter-finals of the 2010 edition in South Africa - their best-ever result at the global gathering - Paraguay's wait for another appearance at the quadrennial event looks set to stretch to the two-decade mark.
The White and Red - who have automatically qualified for the 2030 World Cup as anniversary match co-hosts, having been involved in the inaugural edition 94 years ago - have a mere 10 points on the board from nine contests thus far, one of which was gleaned on October 10.
Alfaro's crop were barely able to venture out of their own half against Ecuador, boasting just 23% of the ball and facing 15 shots, but the Paraguayan defence stood tall to come away with a hard-earned clean sheet and take their side into double figures for points.
Paraguay's current eighth-placed ranking would not suffice for qualification - only the top six automatically go through - but the White and Red have enjoyed a mini-revival of sorts in the past few weeks, now unbeaten in three straight World Cup qualifiers.
Two tremendous results in September saw Paraguay hold Uruguay to a goalless draw before stunning the continent with a 1-0 beating of five-time winners Brazil, meaning that Alfaro's sturdy side have kept three straight clean sheets ahead of the visit of Venezuela.
Paraguay and Venezuela can share a joke when it comes to thwarting the big boys of South American football, as Tuesday's visitors to Asuncion incredibly held reigning world champions Argentina to their first draw of the qualifying process on matchday nine.
Two former Premier League stars were on the scoresheet at Estadio Monumental, as Nicolas Otamendi's opener preceded Salomon Rondon's 45th goal for his country, one which allowed Venezuela to steal a point off of the 2022 World Cup winners.
The resident stalemate specialists in CONMEBOL World Cup qualifying, Fernando Batista's side have drawn five of their nine contests so far - more than any other side - but their modest total of 11 points has them seventh in the 10-nation table, which would put them in next year's inter-confederation playoffs.
For a nation that has never competed at a World Cup finals before, Venezuela's record of just one loss from their last eight qualifying games is highly commendable, as was their 1-0 victory over Paraguay in qualifying 13 months ago.
Tuesday's hosts have traditionally had the better of previous battles, though, winning 19 of their 29 head-to-heads down the years, and it took until the 13th attempt in 2001 for Venezuela to finally get one over the 2010 World Cup quarter-finalists.
Paraguay World Cup Qualifying - South America form:
W
D
L
D
W
D
Paraguay form (all competitions):
L
L
L
D
W
D
Venezuela World Cup Qualifying - South America form:
W
D
D
L
D
D
Venezuela form (all competitions):
W
W
L
L
D
D
Team News
Inter Miami midfielder Diego Gomez and Atletico Mineiro defender Junior Alonso were both missing from the Paraguay squad last week due to yellow card accumulation, but the pair are now back at Alfaro's disposal for Tuesday's game.
Alonso's return could see the 31-year-old come in on the left-hand side for Agustin Sandez, who made his debut for his country in the Ecuador stalemate, but Alfaro should not give any consideration to changing his three-man central barrier.
Ex-West Ham United defender Fabian Balbuena - now on the Dynamo Moscow roster - will be among those reprising their roles, while Brighton & Hove Albion attacker Julio Enciso could start on the left of a front three, with Newcastle United's Miguel Almiron on the opposite flank.
While two Paraguayan players are returning from the naughty step, Venezuela midfielder Jose Martinez is now suspended for his own accumulation of bookings, although he came off with an injury in the dying embers of the draw with Argentina anyway.
Kaizer Chiefs midfielder Edson Castillo - a late call-up to the Venezuela squad - replaced his stricken teammate in added time against the reigning world champions and is seemingly first in line to step in for the banned Martinez on Tuesday.
Once again, Venezuela's all-time leading appearance maker and goalscorers will start in the same team - Rondon leads the line as captain Tomas Rincon prepares to win his 138th cap for his nation; his first 137 appearances have brought just the one goal.
Paraguay possible starting lineup:
Fernandez; Balbuena, Gomez, Alderete; Caceres, Cubas, Bobadilla, Alonso; Almiron, Arce, Enciso
Venezuela possible starting lineup:
Romo; Gonzalez, Osorio, Ferraresi, Aramburu; Castillo, Rincon, Herrera; Savarino, Rondon, Soltedo
We say: Paraguay 0-0 Venezuela
Paraguay's case is most certainly a peculiar one, as even though the hosts have scored the fewest goals in CONMEBOL qualifying - a mere two - they have only allowed three at the other end, by far the best defensive record on the continent.