Meanwhile, this weekend's visitors head into the clash aiming to snap a six-game winless run and give themselves a glimmer of hope in the battle for survival.
Match preview
PSV made it three wins from their last four matches as they cruised to an emphatic 5-1 victory over AZ Alkmaar when the sides went head to head on Saturday.
Two goals from Luuk de Jong and a Johan Bakayoko strike put Peter Bosz's men in the driving seat before Vangelis Pavlidis pulled one back after which Joey Veerman and Jesper Uneken sealed the deal.
As a result, De Rood-witten are still nine points clear of defending champions Feyenoord at the top of the Eredivisie table heading into the final five rounds of games.
Coming up next is the challenge of an opposing outfit who boast just one win from the most recent 21 editions of this fixture dating back to 2014.
Unbeaten in 12 straight home involvements leading up to Saturday's affair, the hosts are flying in front of their fans and will fancy themselves to get the job done here.
Vitesse were beaten for the third game running following a comprehensive 3-0 thrashing against NEC Nijmegen in Sunday's encounter at GelreDome.
Off the back of a drab opening half, Edward Sturing's men fell behind to Mees Hoedemakers's 65th-minute opener before a late Sontje Hansen double put the result beyond doubt.
With just 17 points picked up from 29 league matches so far, Geel en Zwart remain rooted to the bottom of the standings, five points adrift of safety.
Currently with the second-worst away defensive record in the division this term, Saturday's visitors will need to be wary of another meltdown on the road.
PSV Eindhoven Eredivisie form:
D
W
W
L
W
W
PSV Eindhoven form (all competitions):
W
L
W
L
W
W
Vitesse Eredivisie form:
L
L
D
L
L
L
Team News
PSV Eindhoven's Ismael Saibari has not featured since February due to a muscle injury and the midfielder is a doubt for Saturday's clash.
Twenty-eight-year-old Hirving Lozano is also out of contention for the home side as he prepares to sit out a third consecutive game through injury.
Dominik Oroz is suspended for Vitesse here having incurred a one-game suspension as a result of his yellow card against NEC last time out.
Fode Fofana and Miliano Jonathans are both ruled out for the away side through knee injuries, while Mexx Meerdink continues to nurse a groin problem.
PSV Eindhoven possible starting lineup:
Benitez; Teze, Schouten, Boscagli, Dest; Veerman, Junior; Bakayoko, Til, Tillman; De Jong
Vitesse possible starting lineup:
Room; Arcus, Isimat-Mirin, Hendriks, Pinto; Aaronson, Tielemans, Meulensteen; De Regt, Buitink, Kozlowski