They travel to face Newell's Old Boys in the Argentina Primera Division, who just so happen to be the last team that the visitors defeated.
Match preview
Newell's OB heads into this weekend on the back of a 1-0 defeat against Velez Sarsfield despite the fact they managed eight shots throughout the game.
It marked their first loss in the second phase of the Argentina Primera Division, but the fact that they won their first match has left the club in 12th place.
That win was a 2-0 result against Platense where Newell's OB left both of their goals until the final 10 minutes of the game, something they will look to avoid doing as late this time around.
Throughout the first phase of the competition, the hosts were stronger in away fixtures, having only managed three wins out of eight at home, with a lack of goals being the problem.
Newell's OB only scored seven times in those matches, averaging less than a goal per game which is form that they will need to change this time around.
The visitors will take confidence from the fact their opponents failed to put the ball in the back of the net against them earlier this season, which proved to be a tight game.
Defensa defeated Newell's OB by a goal to nil with Santiago Ramos Mino getting the decisive moment, and that is a result that the team will be keen to repeat.
Pablo Quatrocchi's men have failed to win a game since that match back in April, putting together a six-match run in all competitions without securing a win.
It is something that Defensa needs to alter sooner rather than later if they want to start progressing up the division in phase two, but they have been more competitive across their past two fixtures.
Defensa have showcased more fighting spirit after consecutive draws in their last two outings, and making the step up from that now would help the team start progressing up the division.
Newell's Old Boys Argentine Primera Division form:
D
W
L
L
W
L
Defensa y Justicia Argentine Primera Division form:
W
W
W
L
L
D
Defensa y Justicia form (all competitions):
L
L
L
L
D
D
Team News
David Sotelo is still out of action at the moment for the hosts due to an ACL injury, and he is expected to be out for a while longer yet.
Brian Aguirre could force himself into the starting lineup this time out after scoring as a substitute during Newell OB's last victory.
The visitors are without a trio of wingers at the moment due to a variety of injuries, with Gaston Togni, David Barbona and Matias Sosa all on the sidelines at the moment.
After a more positive performance during their most recent outing there could be an unchanged starting XI this time out as the team looks to keep building momentum.
Newell's Old Boys possible starting lineup:
Hoyos; Mendez, Velazquez, Glavinovich, Martino; Cacciabue, R. Fernandez, Aguirre; May; Gonzalez, Ramirez
Defensa y Justicia possible starting lineup:
Fiermarin; Tripichio, Aguilera, Lucero, Soto; Lopez, Gutierrez; Herrera, Echevarria, Alanis; Fernandez
We say: Newell's Old Boys 2-0 Defensa y Justicia
Defensa might have picked up three points the last time these two teams met, but this is going to be a tricky test for them this time around.
The poor form that the visitors are bringing into this game coupled with the fact that Newell's OB are at home should lead to them winning.