The hosts are still winless in the league this term, while their visitors go in search of consecutive victories having notched up a first win last time out.
Match preview
New England Revolution were on the receiving end of a narrow 2-1 defeat at the hands of FC Cincinnati when the teams went head-to-head on Sunday evening.
Caleb Porter's men conceded quickfire strikes from Yuya Kubo and Luciano Acosta two minutes apart before pulling one back through Giacomo Vrioni.
As a result, the Revs remain rooted to the bottom of the Eastern Conference of the MLS table and are already four points adrift in the race for playoff contention.
Next up is the challenge of an opposing outfit with little to choose between the sides over the last five meetings which have all ended in stalemates.
Having not won a league game on home turf since October, Saturday's hosts will be keen to kickstart their season with a much-needed victory.
Chicago Fire showed great resolve to come out on top from a thrilling contest against CF Montreal which ended 4-3 at the Soldier Field on Saturday.
Two goals from Matias Coccaro and a Dominik Yankov strike saw Frank Klopas's men trail 3-1 heading into the final 20 minutes, where Brian Gutierrez, Hugo Cuypers and Kellyn Acosta all netted to complete a remarkable turnaround.
With four points picked up from as many matches so far, the Men in Red sit 10th in the standings, just one point outside the play-in places.
Unbeaten in all but one of their last five matches on the road, Saturday's visitors have been a force to reckon with on the road of late.
New England Revolution Major League Soccer form:
New England Revolution form (all competitions):
W
L
W
L
D
L
Chicago Fire Major League Soccer form:
Team News
New England's Dylan Borrero is still battling with a knee injury which has seen him fail to feature since the early exchanges of last season.
The home side will also be without the services of Brandon Bye, who is without an appearance in seven months due to a long-term injury.
Since returning from suspension, Giacomo Vrioni has found the back of the net in two of his three matches, making him one to keep an eye on.
Andrew Gutman is set to sit out a fourth straight game through a muscle problem, while Federico Navarro remains a major doubt through injury.
Victor Bezerra misses out once again for the visitors this weekend, although the 24-year-old is drawing increasingly closer to a return to action.
New England Revolution possible starting lineup:
Ravas; Lima, Kessler, Romney, Jones; Harkes, Kaye; Chancalay, Gil, Bajraktarevic; Vrioni
Chicago Fire possible starting lineup:
Brady; Arigoni, Salquist, Czichos, Gasper; Acosta, Herbers; Haile-Selassie, Shaqiri, Gutierrez; Cuypers