The Lions were narrow winners during their most recent pre-season fixture, whereas the Saints suffered defeat to second-tier opposition on Wednesday night.
Match preview
Millwall are back on home soil following a week-long training camp in Spain, where the Lions pitted their wits against Premier League Nottingham Forest and third-tier Spanish side Real Murcia, with Neil Harris's troops enduring a mixed period in terms of performances and results.
A first defeat of the summer arrived against the Tricky Trees due to strikes from Chris Wood and Callum Hudson-Odoi, however Millwall returned to winning ways three days later at Pinatar Arena, where goals either side of the half-time break from Tom Bradshaw and Tom Leahy secured victory.
For the first time since the end of last season, the Lions are back at their intimidating home this weekend, although Harris's side were not too amazing at The Den during the 2023-24 campaign, collecting 32 points from 23 second-tier games at the venue, meaning that they ranked 16th in terms of home record.
Following 42 and 28-goal campaigns in the National League and League Two respectively over the past two terms for Notts County, Macaulay Langstaff will be looking to make the step up to the Championship, hopefully firing his new employers towards top-six contention.
The most recent fixture between these two sides was a memorable one for the Lions, who welcomed Harris back into the managerial hotseat following the sacking of Joe Edwards in February, with goals from Japhet Tanganga and flying Dutchman Zian Flemming at St Mary's Stadium securing the visitors a shock 2-1 win.
Following three straight wins at the beginning of their preparations for a return to the Premier League, Southampton were brought back down to earth at the Kassam Stadium on Wednesday night, when League One playoff winners Oxford United recorded a 2-0 victory over their top-flight visitors.
By Russell Martin's own admission during his post-match press conference, the Saints lacked physicality and character in the first period and found themselves two goals behind at the break, with former Cardiff City striker Mark Harris and Portuguese attacker Ruben Rodrigues making the net ripple.
Despite a disappointing evening's work against the second-tier U's, Southampton have enjoyed considerable cause for optimism so far this week, with the South Coast club sealing the permanent signing of Villarreal's Ben Brereton Diaz, who netted six goals in 14 Premier League matches for Sheffield United last season.
Ahead of a daunting top-flight trip to St James' Park where Newcastle United await on the opening weekend of the Premier League term in a fortnight, the Saints have three more pre-season tests, facing Millwall at The Den on Saturday, before home meetings with Getafe and Lazio.
Southampton have only travelled to The Den twice over the past decade and both times the visitors have managed to win, with a 93rd-minute goal from Scotland international Ryan Fraser sealing maximum points for the Saints against Adam Barrett's Millwall in November 2023.
Millwall friendly form:
Southampton friendly form:
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Team News
After undergoing multiple surgeries on injuries earlier in the summer, Millwall's Joe Bryan is back amongst his teammates and could start this weekend.
The Lions are still without the services of goalkeeper Connal Trueman, who suffered an injury at the beginning of July and has failed to feature since.
As a result, either Liam Roberts or summer arrival Lukas Jensen will start in between the sticks for the hosts at The Den versus the Saints.
Southampton face a number of key decisions in midfield ahead of the new season, with youngster Shea Charles recently linked to Scottish giants Celtic.
Martin has insisted that the Saints need more reinforcements to their squad, possibly in the engine room, where Flynn Downes is set to be the first name on the teamsheet.
Millwall possible starting lineup:
Roberts; Wallace, Harding, Tanganga, Leonard; Saville, Honeyman, Esse, Emakhu; Bradshaw, Langstaff
Southampton possible starting lineup:
McCarthy; Sugawara, Edwards, Harwood-Bellis, Manning; Downes, Smallbone, Aribo; Edozie, Armstrong, Brereton Diaz
We say: Millwall 0-1 Southampton
Just a week out from their Championship opener, Millwall are likely to field a strong XI for Saturday afternoon's clash with Southampton.