The top-flight side are looking to return to winning ways in the first-round clash after drawing each of their last three matches by a 1-1 scoreline.
Match preview
Sixth-tier Manises are competing in round one after they successfully negotiated a preliminary round clash against Dolores.
Champi, Marc Cantero and Javi Trilles all got on the scoresheet to fire their side to a 3-1 away win over their eighth-tier opponents.
Manises have followed that successful cup outing with a 2-1 home win against Quart de Poblet and a goalless home draw against Requena.
Those results have moved Manises onto 10 points in the C Valenciana - Nord, leaving them in 10th position of a 16-team league.
They will now turn their focus to a dream Copa del Rey clash against a La Liga opponent, and while it may be a difficult night on the pitch, they will try to make full use of home advantage, having avoided defeat in each of their last four home games (W1, D3).
Meanwhile, Getafe will carry a four-game unbeaten run into Thursday's contest, although they have had to settle for draws in each of their last three outings.
After beating Alaves 2-0, the Azulones went on to play out 1-1 draws against Osasuna and Villarreal, before they repeated that scoreline in Sunday's home clash against Jose Bordalas's former side, Valencia.
Mauro Arambarri netted a 90th-minute penalty to salvage a point which could have become all three were it not for a spectacular double save from Giorgi Mamardashvili in stoppage time.
Having collected a total of 10 points from their 11 league matches, the Azulones are currently sitting in 15th position in La Liga, with one point separating them from the drop zone.
The La Liga side will put their survival bid on hold as they prepare for their first Copa del Rey match of the season, and while they will be the heavy favourites, they will have to remain professional if they are to progress and avoid a first-round exit for the first time since 1999-2000.
Manises Copa del Rey form:
Manises form (all competitions):
Getafe form (all competitions):
D
L
W
D
D
D
Team News
Adrian Munoz is set to line up in goal for Manises, with the goalkeeper expected to be shielded by the central defensive pairing of Iker Peiro and Imanol Alberdi.
Guillem Baixauli is expected to spearhead the Manises attack, and he will hope to receive support from the likes of Alejandro Pastor, Marc Cantero and Javi Trilles.
Meanwhile, Getafe striker Borja Mayoral is unlikely to be involved after missing the last two matches with a muscle problem.
Jiri Letacek will be given the chance to start in goal, while Allan Nyom, Nabil Aberdin, Juan Berrocal and David Arguelles could be brought into the backline.
There may also be starting places for Peter Federico, Carles Alena, Yellu Santiago and Christantus Uche.
Manises possible starting lineup:
Munoz; Cortes, Peiro, Alberdi, Penades; Champi, Gonzalez; Pastor, Cantero, Trilles, Baixauli
Getafe possible starting lineup:
Letacek; Nyom, Aberdin, Berrocal, Arguelles; Peter, Alena, Santiago, Sola; Uche, Rodriguez
We say: Manises 1-3 Getafe
Getafe are not a side known for their free-scoring ability, but with the top-flight side set to face a sixth-tier team, we believe their La Liga quality will help them claim a relatively comfortable victory in Thursday's first-round tie.