The Red Devils have lost new signing Leny Yoro for the next three months with the foot injury he sustained against Arsenal, while Rasmus Hojlund could be missing for six weeks with a hamstring concern.
In addition, Marcus Rashford and Antony both picked up knocks in Wednesday's success over Real Betis, and taking both the tight turnaround and upcoming Community Shield into account, neither of them should feature at the Williams-Brice Stadium.
Instead, Hannibal Mejbri might be given a chance to impress on the left flank, despite talk of a possible switch to Rangers, as Ten Hag shuffles his attacking resources in response to recent injury blows.
Mason Mount is also a candidate to start in the final third, where Scott McTominay could be deployed a false nine, thereby forcing Jadon Sancho down to the bench as the bright Amad Diallo keeps his place.
There should be some continuity further back, though, as Casemiro and Christian Eriksen prepare to reprise their midfield partnership, while Aaron Wan-Bissaka and Harry Amass ought to hold their places out wide.
However, Jonny Evans and Andre Onana could add a touch of freshness to the rearguard alongside Victor Lindelof, as Tom Heaton and Harry Maguire drop out.
Manchester United possible starting lineup:
Onana; Wan-Bissaka, Evans, Lindelof, Amass; Casemiro, Eriksen; Diallo, Mount, Mejbri; McTominay