The Red Devils recorded a 2-0 win over PAOK in the Europa League on Thursday night, with that result following a 1-1 draw with Chelsea in the league last weekend.
Man United are currently 13th in the Premier League table, six points behind fourth-placed Chelsea, and this match will mark the team's last fixture before Ruben Amorim arrives as head coach from Sporting Lisbon.
Here, Sports Mole rounds up Man United's injury and suspension news ahead of their contest with Leicester, who are currently 15th in the table, just two points behind their opponents at Old Trafford.
Amad Diallo
Status: Minor doubt
Type of injury: Unknown
Possible return date: November 10 (vs. Leicester)
Amad was forced off in the latter stages of Thursday's clash with PAOK after scoring a brace, and Van Nistelrooy said after the match that the forward would now need to be assessed ahead of the home fixture with Leicester.
Leny Yoro
Status: Out
Type of injury: Foot
Possible return date: December 3 (vs. Arsenal)
Yoro returned to training with Man United ahead of the Europa League clash with PAOK, and the centre-back, who fractured his metatarsal during pre-season, is now closing in on his competitive debut for the Red Devils.
There has been talk of the Frenchman being available for the trip to Ipswich Town on November 24, but it is much more likely that his first appearance for the club will come in the early stages of December.
Tyrell Malacia
Status: Out
Type of injury: Knee
Possible return date: Unknown
Malacia missed the entire 2023-24 season due to a serious knee injury which required two separate operations, and the left-back is still not ready to return, but he is now back in full training and should be available in the not too distant future.
Luke Shaw
Status: Out
Type of injury: Calf
Possible return date: Unknown
Shaw has been absent early in the season due to a calf problem, and the left-back is still not ready to feature, with Erik ten Hag revealing ahead of his departure that the Englishman has had a setback in his recovery.
Kobbie Mainoo
Status: Out
Type of injury: Muscle
Possible return date: November 24 (vs. Ipswich Town)
Mainoo is currently on the sidelines with a muscular problem, but the England international has a strong chance of being available for selection in the team's first match after the November international break.
Toby Collyer
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Collyer has not been in a matchday squad for Man United since the middle of September due to a muscular problem, and the 20-year-old midfielder remains on the sidelines for the 20-time English champions.
Harry Maguire
Status: Out
Type of injury: Muscle
Possible return date: November 24 (vs. Ipswich Town)
Maguire remains on the treatment table with a muscular problem, but there is a slight chance that the centre-back could make his return after the international break against Ipswich.
MANCHESTER UNITED'S SUSPENSION LIST
Man United have no players suspended for the Premier League clash.