Despite the clear increase in quality of opposition from battles in the previous rounds against Tranmere Rovers and Walsall, Foxes head coach Steve Cooper is likely to continue with a theme of rotation in this competition.
A penalty-shootout hero versus the Saddlers last month in the third round, Danny Ward will take his place in between the sticks for the trip to Old Trafford.
Owing to Victor Kristansen's muscle injury, Leicester are short on options in the full-back roles, meaning that James Justin could retain his spot in the side from Friday night's loss to Nottingham Forest in the Premier League.
Former England international Conor Coady is set to replace Wout Faes at the heart of the backline, although Caleb Okoli could retain his starting berth due to the ankle problems of Jannik Vestergaard.
Linked with a January switch, out-of-favour midfielder Boubakary Soumare is likely to be handed a rare start alongside Oliver Skipp in the engine room.
With Patson Daka yet to kick a competitive ball for the Foxes this season because of an ankle injury, Cooper has the choice between club legend Jamie Vardy and summer arrival Odsonne Edouard to lead the visitors' line.
Leicester City possible starting lineup: Ward; Justin, Coady, Okoli, Thomas; Soumare, Skipp, McAteer, El Khannouss, De Cordova-Reid; Edouard
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