The Red Devils are currently sixth in the table, 13 points off fourth spot, while Burnley sit 19th, three points from safety in England's top flight, and here Sports Mole rounds up the team news.
MANCHESTER UNITED vs. BURNLEY
MANCHESTER UNITED
Out: Tyrell Malacia (knee), Anthony Martial (groin), Luke Shaw (thigh), Lisandro Martinez (calf), Jonny Evans (muscle), Raphael Varane (muscle), Marcus Rashford (foot), Willy Kambwala (unspecified)
Doubtful: Mason Mount (unspecified)
Sports Mole's predicted XI: Onana; Wan-Bissaka, Casemiro, Maguire, Dalot; Mainoo, McTominay; Amad, Fernandes, Garnacho; Hojlund
BURNLEY
Out: Aaron Ramsey (knee), Jordan Beyer (thigh), Nathan Redmond (thigh), Ameen Al-Dakhil (unspecified), Luca Koleosho (knee)
Doubtful: None
Sports Mole's predicted XI: Muric; Assignon, O'Shea, Esteve, Taylor; Vitinho, Cullen, Berge, Larsen; Foster, Odobert
For data analysis of the most likely results, scorelines and more for this match please click here.