While the Hatters came from behind to beat Bournemouth 2-1 last weekend, the Citizens played out a thrilling 3-3 draw with Real Madrid in the Champions League quarter-finals on Tuesday, and here, Sports Mole rounds up all of the latest team news for the two clubs.
MANCHESTER CITY vs. LUTON TOWN
MANCHESTER CITY
Out: None
Doubtful: Kyle Walker (hamstring), Nathan Ake (calf), Phil Foden (knock), Kevin De Bruyne (illness)
Sports Mole's predicted XI: Ortega; Akanji, Dias, Gvardiol; Lewis, Kovacic; Doku, De Bruyne, Nunes, Grealish; Haaland
LUTON TOWN
Out: Issa Kabore (ineligible), Tom Lockyer (chest), Marvelous Nakamba (knee), Jacob Brown (knee), Elijah Adebayo (thigh), Amari'i Bell (thigh), Chiedozie Ogbene (thigh), Albert Sambi Lokonga (thigh), Dan Potts (thigh), Mads Andersen (calf)
Doubtful: Gabriel Osho (knee)
Sports Mole's predicted XI: Kaminski; Hashioka, Mengi, Burke; Onyedinma, Barkley, Clark, Doughty; Townsend, Chong; Morris
For data analysis of the most likely results, scorelines and more for this match please click here.
Sevilla 
Rayo Vallecano 
Ajax 
Pec Zwolle 
Palermo 
Sampdoria 
Ipswich 
Manchester Utd 
Napoli 
Roma 
Moreirense 
FC Porto 
Leganes 
Real Madrid 
Lazio 
Bologna 
Empoli 
Udinese 
CSKA Moscow 
Rubin 
Slovan Bratislava 
AC Milan 
Sparta Praha 
Atletico Madrid 
Valencia 
Barcelona 
Stade Brestois 29 
Bayer Leverkusen 
Red Bull Salzburg 
Bayern Munich 
Paris Saint Germain 
Inter 
RB Leipzig 
Manchester City 
Feyenoord 
Sporting CP 
Arsenal 
FC Rostov 
Spartak Moscow 
Aston Villa 
Juventus 
Celtic 
Club Brugge 
Dinamo Zagreb 
Borussia Dortmund 
Liverpool 
Monaco 
Benfica 
PSV 
Shakhtar Donetsk 
Lokomotiv Moscow 
Dinamo Moscow 
Anderlecht 
AZ Alkmaar 
Galatasaray 
Dynamo Kyiv 
Viktoria Plzen