Although Mauricio Pochettino's side have recently been criticised, the Blues bounced back with a 6-0 victory over Everton in the Premier League earlier this week.
However, Chelsea have already suffered one heartbreak at Wembley Stadium this season - losing to Liverpool in the EFL Cup final - and Pochettino will be hoping that his side can continue their unbeaten run against the 2023 winners from earlier in the season.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the showdown with Man City in the capital.
Levi Colwill
Status: Major doubt
Type of injury: Toe
Possible return date: April 20 (vs. Man City)
Levi Colwill has been absent since the beginning of March with a toe injury. However, the defender has recently returned to light training and may have an outside chance of returning to the substitutes' bench at the weekend.
Christopher Nkunku
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Christopher Nkunku has been absent since suffering a hamstring injury during the EFL Cup final against Liverpool at the end of February. Although he was initially expected to return after the March international break, the France international remains out of contention.
Wesley Fofana
Status: Out
Type of injury: Knee
Possible return date: Unknown
Wesley Fofana faces a battle to return to action before the end of the campaign due to the serious knee injury that he suffered ahead of the 2023-24 season. All things considered, he is highly unlikely to be risked until next season.
Reece James
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Reece James underwent hamstring surgery towards the end of last year, and it is currently unclear when the England international could be available for selection.
Lesley Ugochukwu
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Lesley Ugochukwu picked up a hamstring injury towards the end of 2023, and Chelsea have not offered any indications of when he could potentially return to first-team training.
Romeo Lavia
Status: Out
Type of injury: Thigh
Possible return date: Unknown
Romeo Lavia has made just one substitute appearance since joining Chelsea last summer, and the midfielder will not be available for selection until the 2024-25 campaign due to a thigh problem.
Robert Sanchez
Status: Minor doubt
Type of injury: Illness
Possible return date: April 20 (vs. Man City)
As a result of a knee injury and illness, Robert Sanchez has been limited to FA Cup appearances since the turn of the year. However, having missed the game with Everton due to the latter, the goalkeeper will only featured on the substitutes' bench at best.
Raheem Sterling
Status: Minor doubt
Type of injury: Illness
Possible return date: April 20 (vs. Man City)
Raheem Sterling was a notable absentee from the squad against Everton due to illness. However, the expectation is that he will be back in the squad for this game.
Enzo Fernandez
Status: Major doubt
Type of injury: Unknown
Possible return date: April 20 (vs. Man City)
Reports have suggested that Enzo Fernandez could undergo surgery for a hernia problem in the near future. However, it remains unclear whether he will make himself available for this game before spending several weeks on the sidelines.
Axel Disasi
Status: Minor doubt
Type of injury: Unknown
Possible return date: April 20 (vs. Man City)
Axel Disasi missed the Everton game due to an unknown issue that was described as "minor". The likelihood is that he will be back in the fold for the contest at Wembley.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this match. However, midfielder Cesare Casadei is unavailable due to being cup-tied through representing Leicester City earlier in the competition.