Erling Haaland, the Premier League's Player of the Month for August, stole the show once again as he netted two goals to take his tally for the season to nine after just four matches.
The Citizens made the worst possible start as they fell behind after just 22 seconds when Yoane Wissa headed home from close range, following a mishap in the six-yard box from John Stones and Ederson.
Brentford's fast start caused a City side surprisingly lacking composure several problems in the early exchanges, but the hosts eventually stamped their authority on proceedings and turned the contest on its head just after the hour mark.
Haaland restored parity for the Citizens with a deflected right-footed shot across goal, before delicately dinking his second over Mark Flekken after bursting through on goal.
A somewhat muted start to the second half was largely dominated by Pep Guardiola's men who came close to extending their lead through Savinho and Haaland, the latter was denied a record-breaking third successive hat-trick by the face of the post 10 minutes from time.
Brentford substitute Yegor Yarmolyuk dragged a decent effort wide in stoppage time, but Man City held on to claim maximum points and they remain top of the Premier League table with a 100% record after four matches, while Thomas Frank's Brentford have slipped to eighth place after suffering their second defeat of the season.
MAN CITY VS. BRENTFORD HIGHLIGHTS
Yoane Wissa goal vs. Man City (1st min, Man City 0-1 Brentford)
Brentford could not have got of to a better start at the Etihad as they opened the scoring after just 22 seconds straight from their own kickoff!
The Bees pumped the ball forward and it eventually fell to Keane Lewis-Potter at the back post. He headed the ball across goal, with neither John Stones or Ederson able to clear their lines, and it popped up nicely for Yoane Wissa to head home his third goal of the campaign from close range.
Erling Haaland goal vs. Brentford (19th min, Man City 1-1 Brentford)
Man City restored parity through who else but Erling Haaland inside the opening 19 minutes. Both Kyle Walker and Kevin De Bruyne initially combined before the latter was tackled by Christian Norgaard, and the ricochet that followed picked out Haaland inside the area.
The Norwegian needed little time to swivel and fire a right-footed shot inside the far post via an Ethan Pinnock deflection.
Erling Haaland goal vs. Brentford (33rd min, Man City 2-1 Brentford)
Man City put themselves in front for the first time in the contest just after the half-hour mark courtesy of a delicate finish from Haaland - his ninth Premier League goal of the campaign and 99th for the Citizens.
Ederson decided to go long and pumped the ball forward towards Haaland, who gently out-muscled Pinnock before bursting through on goal and dinking a sweet finish beyond Mark Flekken into the far corner.
MAN OF THE MATCH - ERLING HAALAND
Erling Haaland was in the right place at the right time to fire home his first goal before expertly dinking his second beyond Flekken, and he almost completed his hat-trick late on, only to be denied by the post.
The Norwegian makes scoring in the Premier League look so easy and, once again, his clinical touch in the final third proved to be crucial for Man City this afternoon.
MAN CITY VS. BRENTFORD MATCH STATS
Possession: Man City 54%-46% Brentford
Shots: Man City 18-7 Brentford
Shots on target: Man City 8-5 Brentford
Corners: Man City 12-3 Brentford
Fouls: Man City 9-3 Brentford
BEST STATS
WHAT NEXT?
Man City will now turn their attention to the newly-expanded Champions League and their first game in the League Phase of the competition at home to Serie A champions Inter Milan next Wednesday.
As for Brentford, they are next in action on Tuesday when they welcome League One outfit Leyton Orient to the Gtech Community Stadium for a third-round tie in the EFL Cup.